diff --git a/CHANGELOG.md b/CHANGELOG.md
index 826abf3786..b2d76424c5 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -38,6 +38,7 @@
 - [#5239](https://github.com/blockscout/blockscout/pull/5239) - Add accounting for block rewards in `getblockreward` api method
 
 ### Chore
+- [#5506](https://github.com/blockscout/blockscout/pull/5506) - Refactor config files
 - [#5480](https://github.com/blockscout/blockscout/pull/5480) - Remove duplicate of balances_params_to_address_params function
 - [#5473](https://github.com/blockscout/blockscout/pull/5473) - Refactor daily coin balances fetcher
 - [#5458](https://github.com/blockscout/blockscout/pull/5458) - Decrease min safe polling period for realtime fetcher
diff --git a/apps/block_scout_web/config/config.exs b/apps/block_scout_web/config/config.exs
index 8392cfdda8..9fc2c0ef2f 100644
--- a/apps/block_scout_web/config/config.exs
+++ b/apps/block_scout_web/config/config.exs
@@ -55,31 +55,34 @@ config :block_scout_web,
   re_captcha_client_key: System.get_env("RE_CAPTCHA_CLIENT_KEY", nil),
   admin_panel_enabled: System.get_env("ADMIN_PANEL_ENABLED", "") == "true"
 
+default_api_rate_limit = 50
+default_api_rate_limit_str = Integer.to_string(default_api_rate_limit)
+
 global_api_rate_limit_value =
   "API_RATE_LIMIT"
-  |> System.get_env("50")
+  |> System.get_env(default_api_rate_limit_str)
   |> Integer.parse()
   |> case do
     {integer, ""} -> integer
-    _ -> 50
+    _ -> default_api_rate_limit
   end
 
 api_rate_limit_by_key_value =
   "API_RATE_LIMIT_BY_KEY"
-  |> System.get_env("50")
+  |> System.get_env(default_api_rate_limit_str)
   |> Integer.parse()
   |> case do
     {integer, ""} -> integer
-    _ -> 50
+    _ -> default_api_rate_limit
   end
 
 api_rate_limit_by_ip_value =
   "API_RATE_LIMIT_BY_IP"
-  |> System.get_env("50")
+  |> System.get_env(default_api_rate_limit_str)
   |> Integer.parse()
   |> case do
     {integer, ""} -> integer
-    _ -> 50
+    _ -> default_api_rate_limit
   end
 
 config :block_scout_web, :api_rate_limit,
diff --git a/apps/explorer/config/config.exs b/apps/explorer/config/config.exs
index c8986bfab6..2ce8c0c4ea 100644
--- a/apps/explorer/config/config.exs
+++ b/apps/explorer/config/config.exs
@@ -5,6 +5,9 @@
 # is restricted to this project.
 import Config
 
+disable_indexer = System.get_env("DISABLE_INDEXER")
+disable_webapp = System.get_env("DISABLE_WEBAPP")
+
 # General application configuration
 config :explorer,
   ecto_repos: [Explorer.Repo],
@@ -18,7 +21,7 @@ config :explorer,
     if(System.get_env("UNCLES_IN_AVERAGE_BLOCK_TIME") == "true", do: true, else: false),
   healthy_blocks_period: System.get_env("HEALTHY_BLOCKS_PERIOD") || :timer.minutes(5),
   realtime_events_sender:
-    if(System.get_env("DISABLE_WEBAPP") != "true",
+    if(disable_webapp != "true",
       do: Explorer.Chain.Events.SimpleSender,
       else: Explorer.Chain.Events.DBSender
     )
@@ -29,7 +32,7 @@ config :explorer, Explorer.Counters.AverageBlockTime,
 
 config :explorer, Explorer.Chain.Events.Listener,
   enabled:
-    if(System.get_env("DISABLE_WEBAPP") == "true" && System.get_env("DISABLE_INDEXER") == "true",
+    if(disable_webapp == "true" && disable_indexer == "true",
       do: false,
       else: true
     )
@@ -42,8 +45,8 @@ config :explorer, Explorer.ChainSpec.GenesisData,
 
 config :explorer, Explorer.Chain.Cache.BlockNumber,
   enabled: true,
-  ttl_check_interval: if(System.get_env("DISABLE_INDEXER") == "true", do: :timer.seconds(1), else: false),
-  global_ttl: if(System.get_env("DISABLE_INDEXER") == "true", do: :timer.seconds(5))
+  ttl_check_interval: if(disable_indexer == "true", do: :timer.seconds(1), else: false),
+  global_ttl: if(disable_indexer == "true", do: :timer.seconds(5))
 
 address_sum_global_ttl =
   "CACHE_ADDRESS_SUM_PERIOD"
@@ -64,9 +67,11 @@ config :explorer, Explorer.Chain.Cache.AddressSumMinusBurnt,
   ttl_check_interval: :timer.seconds(1),
   global_ttl: address_sum_global_ttl
 
+cache_address_with_balances_update_interval = System.get_env("CACHE_ADDRESS_WITH_BALANCES_UPDATE_INTERVAL")
+
 balances_update_interval =
-  if System.get_env("CACHE_ADDRESS_WITH_BALANCES_UPDATE_INTERVAL") do
-    case Integer.parse(System.get_env("CACHE_ADDRESS_WITH_BALANCES_UPDATE_INTERVAL")) do
+  if cache_address_with_balances_update_interval do
+    case Integer.parse(cache_address_with_balances_update_interval) do
       {integer, ""} -> integer
       _ -> nil
     end
@@ -121,9 +126,11 @@ config :explorer, Explorer.Counters.BlockPriorityFeeCounter,
 config :explorer, Explorer.Chain.Cache.GasUsage,
   enabled: System.get_env("CACHE_ENABLE_TOTAL_GAS_USAGE_COUNTER") == "true"
 
+cache_bridge_market_cap_update_interval = System.get_env("CACHE_BRIDGE_MARKET_CAP_UPDATE_INTERVAL")
+
 bridge_market_cap_update_interval =
-  if System.get_env("CACHE_BRIDGE_MARKET_CAP_UPDATE_INTERVAL") do
-    case Integer.parse(System.get_env("CACHE_BRIDGE_MARKET_CAP_UPDATE_INTERVAL")) do
+  if cache_bridge_market_cap_update_interval do
+    case Integer.parse(cache_bridge_market_cap_update_interval) do
       {integer, ""} -> integer
       _ -> nil
     end
@@ -141,7 +148,7 @@ config :explorer, Explorer.KnownTokens, enabled: System.get_env("DISABLE_KNOWN_T
 
 config :explorer, Explorer.Integrations.EctoLogger, query_time_ms_threshold: :timer.seconds(2)
 
-config :explorer, Explorer.Market.History.Cataloger, enabled: System.get_env("DISABLE_INDEXER") != "true"
+config :explorer, Explorer.Market.History.Cataloger, enabled: disable_indexer != "true"
 
 config :explorer, Explorer.Chain.Cache.MinMissingBlockNumber, enabled: System.get_env("DISABLE_WRITE_API") != "true"
 
@@ -182,7 +189,7 @@ if System.get_env("METADATA_CONTRACT") && System.get_env("VALIDATORS_CONTRACT")
     metadata_contract_address: System.get_env("METADATA_CONTRACT"),
     validators_contract_address: System.get_env("VALIDATORS_CONTRACT")
 
-  config :explorer, Explorer.Validator.MetadataProcessor, enabled: System.get_env("DISABLE_INDEXER") != "true"
+  config :explorer, Explorer.Validator.MetadataProcessor, enabled: disable_indexer != "true"
 else
   config :explorer, Explorer.Validator.MetadataProcessor, enabled: false
 end
@@ -191,10 +198,12 @@ config :explorer, Explorer.Chain.Block.Reward,
   validators_contract_address: System.get_env("VALIDATORS_CONTRACT"),
   keys_manager_contract_address: System.get_env("KEYS_MANAGER_CONTRACT")
 
-if System.get_env("POS_STAKING_CONTRACT") do
+pos_staking_contract = System.get_env("POS_STAKING_CONTRACT")
+
+if pos_staking_contract do
   config :explorer, Explorer.Staking.ContractState,
     enabled: true,
-    staking_contract_address: System.get_env("POS_STAKING_CONTRACT"),
+    staking_contract_address: pos_staking_contract,
     eth_subscribe_max_delay: System.get_env("POS_ETH_SUBSCRIBE_MAX_DELAY", "60"),
     eth_blocknumber_pull_interval: System.get_env("POS_ETH_BLOCKNUMBER_PULL_INTERVAL", "500")
 else
@@ -234,20 +243,20 @@ config :spandex_ecto, SpandexEcto.EctoLogger,
   otp_app: :explorer
 
 config :explorer, Explorer.Chain.Cache.Blocks,
-  ttl_check_interval: if(System.get_env("DISABLE_INDEXER") == "true", do: :timer.seconds(1), else: false),
-  global_ttl: if(System.get_env("DISABLE_INDEXER") == "true", do: :timer.seconds(5))
+  ttl_check_interval: if(disable_indexer == "true", do: :timer.seconds(1), else: false),
+  global_ttl: if(disable_indexer == "true", do: :timer.seconds(5))
 
 config :explorer, Explorer.Chain.Cache.Transactions,
-  ttl_check_interval: if(System.get_env("DISABLE_INDEXER") == "true", do: :timer.seconds(1), else: false),
-  global_ttl: if(System.get_env("DISABLE_INDEXER") == "true", do: :timer.seconds(5))
+  ttl_check_interval: if(disable_indexer == "true", do: :timer.seconds(1), else: false),
+  global_ttl: if(disable_indexer == "true", do: :timer.seconds(5))
 
 config :explorer, Explorer.Chain.Cache.Accounts,
-  ttl_check_interval: if(System.get_env("DISABLE_INDEXER") == "true", do: :timer.seconds(1), else: false),
-  global_ttl: if(System.get_env("DISABLE_INDEXER") == "true", do: :timer.seconds(5))
+  ttl_check_interval: if(disable_indexer == "true", do: :timer.seconds(1), else: false),
+  global_ttl: if(disable_indexer == "true", do: :timer.seconds(5))
 
 config :explorer, Explorer.Chain.Cache.Uncles,
-  ttl_check_interval: if(System.get_env("DISABLE_INDEXER") == "true", do: :timer.seconds(1), else: false),
-  global_ttl: if(System.get_env("DISABLE_INDEXER") == "true", do: :timer.seconds(5))
+  ttl_check_interval: if(disable_indexer == "true", do: :timer.seconds(1), else: false),
+  global_ttl: if(disable_indexer == "true", do: :timer.seconds(5))
 
 config :explorer, Explorer.ThirdPartyIntegrations.Sourcify,
   server_url: System.get_env("SOURCIFY_SERVER_URL") || "https://sourcify.dev/server",
diff --git a/apps/indexer/config/config.exs b/apps/indexer/config/config.exs
index d543da2225..80330b9022 100644
--- a/apps/indexer/config/config.exs
+++ b/apps/indexer/config/config.exs
@@ -41,26 +41,24 @@ config :indexer, Indexer.Fetcher.PendingTransaction.Supervisor,
     System.get_env("ETHEREUM_JSONRPC_VARIANT") == "besu" ||
       System.get_env("INDEXER_DISABLE_PENDING_TRANSACTIONS_FETCHER", "false") == "true"
 
+token_balance_on_demand_fetcher_threshold_minutes = System.get_env("TOKEN_BALANCE_ON_DEMAND_FETCHER_THRESHOLD_MINUTES")
+
 token_balance_on_demand_fetcher_threshold =
-  if System.get_env("TOKEN_BALANCE_ON_DEMAND_FETCHER_THRESHOLD_MINUTES") do
-    case Integer.parse(System.get_env("TOKEN_BALANCE_ON_DEMAND_FETCHER_THRESHOLD_MINUTES")) do
-      {integer, ""} -> integer
-      _ -> 60
-    end
-  else
-    60
+  case token_balance_on_demand_fetcher_threshold_minutes &&
+         Integer.parse(token_balance_on_demand_fetcher_threshold_minutes) do
+    {integer, ""} -> integer
+    _ -> 60
   end
 
 config :indexer, Indexer.Fetcher.TokenBalanceOnDemand, threshold: token_balance_on_demand_fetcher_threshold
 
+coin_balance_on_demand_fetcher_threshold_minutes = System.get_env("COIN_BALANCE_ON_DEMAND_FETCHER_THRESHOLD_MINUTES")
+
 coin_balance_on_demand_fetcher_threshold =
-  if System.get_env("COIN_BALANCE_ON_DEMAND_FETCHER_THRESHOLD_MINUTES") do
-    case Integer.parse(System.get_env("COIN_BALANCE_ON_DEMAND_FETCHER_THRESHOLD_MINUTES")) do
-      {integer, ""} -> integer
-      _ -> 60
-    end
-  else
-    60
+  case coin_balance_on_demand_fetcher_threshold_minutes &&
+         Integer.parse(coin_balance_on_demand_fetcher_threshold_minutes) do
+    {integer, ""} -> integer
+    _ -> 60
   end
 
 config :indexer, Indexer.Fetcher.CoinBalanceOnDemand, threshold: coin_balance_on_demand_fetcher_threshold
diff --git a/apps/indexer/lib/indexer/fetcher/coin_balance_on_demand.ex b/apps/indexer/lib/indexer/fetcher/coin_balance_on_demand.ex
index e7989a027e..ac02a8f2d2 100644
--- a/apps/indexer/lib/indexer/fetcher/coin_balance_on_demand.ex
+++ b/apps/indexer/lib/indexer/fetcher/coin_balance_on_demand.ex
@@ -230,7 +230,8 @@ defmodule Indexer.Fetcher.CoinBalanceOnDemand do
         if average_block_time == 0 do
           {:error, :empty_database}
         else
-          block_number - div(:timer.minutes(Application.get_env(:indexer, __MODULE__)[:threshold]), average_block_time)
+          threshold = Application.get_env(:indexer, __MODULE__)[:threshold]
+          block_number - div(:timer.minutes(threshold), average_block_time)
         end
     end
   end
diff --git a/apps/indexer/lib/indexer/fetcher/token_balance_on_demand.ex b/apps/indexer/lib/indexer/fetcher/token_balance_on_demand.ex
index 620586c0ad..c63397736d 100644
--- a/apps/indexer/lib/indexer/fetcher/token_balance_on_demand.ex
+++ b/apps/indexer/lib/indexer/fetcher/token_balance_on_demand.ex
@@ -104,7 +104,8 @@ defmodule Indexer.Fetcher.TokenBalanceOnDemand do
         if average_block_time == 0 do
           {:error, :empty_database}
         else
-          block_number - div(:timer.minutes(Application.get_env(:indexer, __MODULE__)[:threshold]), average_block_time)
+          threshold = Application.get_env(:indexer, __MODULE__)[:threshold]
+          block_number - div(:timer.minutes(threshold), average_block_time)
         end
     end
   end