diff --git a/.github/workflows/config.yml b/.github/workflows/config.yml
index 0f2ad51ee0..a86ad29b1d 100644
--- a/.github/workflows/config.yml
+++ b/.github/workflows/config.yml
@@ -26,6 +26,7 @@ on:
       - 'docker/*'
       - 'docker-compose/*'
   pull_request:
+    types: [opened, synchronize, reopened, labeled]
     branches:
       - master
       - production-optimism
@@ -46,9 +47,30 @@ jobs:
     steps:
       - id: set-matrix
         run: |
-          echo "matrix=$matrixStringifiedObject" >> $GITHUB_OUTPUT
-        env:
-          matrixStringifiedObject: '{"chain-type": ["ethereum", "polygon_edge", "polygon_zkevm", "rsk", "suave", "stability", "filecoin", "optimism"]}'
+          echo "matrix=$(node -e '
+
+            // Add/remove CI matrix chain types here
+            const defaultChainTypes = ["default"];
+            const chainTypes = ["ethereum", "polygon_zkevm", "rsk", "stability", "filecoin", "optimism"];
+            const extraChainTypes = ["suave", "polygon_edge"];
+
+            // Chain type matrix we use in master branch
+            const allChainTypes = [].concat(defaultChainTypes, chainTypes, extraChainTypes);
+
+            const labels = ${{ github.event_name == 'pull_request' && toJson(github.event.pull_request.labels.*.name) || '[]' }};
+            const ciLabels = labels.filter(label => label.startsWith("ci:"));
+            const labeledChainTypes = [].concat(
+              defaultChainTypes.filter(chainType => ciLabels.includes("ci:" + chainType)),
+              chainTypes.filter(chainType => ciLabels.includes("ci:all") || ciLabels.includes("ci:" + chainType)),
+              extraChainTypes.filter(chainType => ciLabels.includes("ci:" + chainType))
+            );
+
+            // Chain type matrix we use in PRs to master branch
+            const ciChainTypes = labeledChainTypes.length > 0 ? labeledChainTypes : defaultChainTypes;
+
+            const matrix = { "chain-type": ${{ github.event_name == 'pull_request' && 'ciChainTypes' || 'allChainTypes' }} };
+            console.log(JSON.stringify(matrix));
+          ')" >> $GITHUB_OUTPUT
 
   build-and-cache:
     name: Build and Cache deps
@@ -215,12 +237,12 @@ jobs:
           mkdir -p priv/plts
           mix dialyzer --plt
         env:
-          CHAIN_TYPE: ${{ matrix.chain-type }}
+          CHAIN_TYPE: ${{ matrix.chain-type != 'default' && matrix.chain-type || '' }}
 
       - name: Run Dialyzer
         run: mix dialyzer --halt-exit-status
         env:
-          CHAIN_TYPE: ${{ matrix.chain-type }}
+          CHAIN_TYPE: ${{ matrix.chain-type != 'default' && matrix.chain-type || '' }}
 
   gettext:
     name: Missing translation keys check
@@ -486,7 +508,7 @@ jobs:
           PGUSER: postgres
           ETHEREUM_JSONRPC_CASE: "EthereumJSONRPC.Case.Nethermind.Mox"
           ETHEREUM_JSONRPC_WEB_SOCKET_CASE: "EthereumJSONRPC.WebSocket.Case.Mox"
-          CHAIN_TYPE: "${{ matrix.chain-type }}"
+          CHAIN_TYPE: ${{ matrix.chain-type != 'default' && matrix.chain-type || '' }}
   test_nethermind_mox_explorer:
     strategy:
       fail-fast: false
@@ -560,7 +582,7 @@ jobs:
           PGUSER: postgres
           ETHEREUM_JSONRPC_CASE: "EthereumJSONRPC.Case.Nethermind.Mox"
           ETHEREUM_JSONRPC_WEB_SOCKET_CASE: "EthereumJSONRPC.WebSocket.Case.Mox"
-          CHAIN_TYPE: "${{ matrix.chain-type }}"
+          CHAIN_TYPE: ${{ matrix.chain-type != 'default' && matrix.chain-type || '' }}
   test_nethermind_mox_indexer:
     strategy:
       fail-fast: false
@@ -626,7 +648,7 @@ jobs:
           PGUSER: postgres
           ETHEREUM_JSONRPC_CASE: "EthereumJSONRPC.Case.Nethermind.Mox"
           ETHEREUM_JSONRPC_WEB_SOCKET_CASE: "EthereumJSONRPC.WebSocket.Case.Mox"
-          CHAIN_TYPE: "${{ matrix.chain-type }}"
+          CHAIN_TYPE: ${{ matrix.chain-type != 'default' && matrix.chain-type || '' }}
   test_nethermind_mox_block_scout_web:
     strategy:
       fail-fast: false
@@ -725,4 +747,4 @@ jobs:
           ACCOUNT_ENABLED: "true"
           ACCOUNT_REDIS_URL: "redis://localhost:6379"
           SOURCIFY_INTEGRATION_ENABLED: "true"
-          CHAIN_TYPE: "${{ matrix.chain-type }}"
+          CHAIN_TYPE: ${{ matrix.chain-type != 'default' && matrix.chain-type || '' }}
diff --git a/PULL_REQUEST_TEMPLATE.md b/PULL_REQUEST_TEMPLATE.md
index bfc691bd1d..6e15223f20 100644
--- a/PULL_REQUEST_TEMPLATE.md
+++ b/PULL_REQUEST_TEMPLATE.md
@@ -25,4 +25,5 @@
   - [ ] If I fixed a bug, I added a regression test to prevent the bug from silently reappearing again.
   - [ ] I checked whether I should update the docs and did so by submitting a PR to https://github.com/blockscout/docs
   - [ ] If I added/changed/removed ENV var, I submitted a PR to https://github.com/blockscout/docs to update the list of env vars at https://github.com/blockscout/docs/blob/master/for-developers/information-and-settings/env-variables.md and I updated the version to `master` in the Version column. Changes will be reflected in this table: https://docs.blockscout.com/for-developers/information-and-settings/env-variables. 
-  - [ ] If I add new indices into DB, I checked, that they are not redundant with PGHero or other tools
+  - [ ] If I added new DB indices, I checked, that they are not redundant with PGHero or other tools.
+  - [ ] If I added/removed chain type, I modified the Github CI matrix and PR labels accordingly.