diff --git a/app/_locales/en/messages.json b/app/_locales/en/messages.json
index f49c27df8..9883154e1 100644
--- a/app/_locales/en/messages.json
+++ b/app/_locales/en/messages.json
@@ -1836,6 +1836,12 @@
   "swapConfirmWithHwWallet": {
     "message": "Confirm with your hardware wallet"
   },
+  "swapContractDataDisabledErrorDescription": {
+    "message": "In the Ethereum app on your Ledger, go to \"Settings\" and allow contract data. Then, try your swap again."
+  },
+  "swapContractDataDisabledErrorTitle": {
+    "message": "Contract data is not enabled on your Ledger"
+  },
   "swapCustom": {
     "message": "custom"
   },
diff --git a/shared/constants/swaps.js b/shared/constants/swaps.js
index 3f345542b..2843821e5 100644
--- a/shared/constants/swaps.js
+++ b/shared/constants/swaps.js
@@ -12,6 +12,7 @@ export const QUOTES_EXPIRED_ERROR = 'quotes-expired';
 export const SWAP_FAILED_ERROR = 'swap-failed-error';
 export const ERROR_FETCHING_QUOTES = 'error-fetching-quotes';
 export const QUOTES_NOT_AVAILABLE_ERROR = 'quotes-not-avilable';
+export const CONTRACT_DATA_DISABLED_ERROR = 'contract-data-disabled';
 export const OFFLINE_FOR_MAINTENANCE = 'offline-for-maintenance';
 export const SWAPS_FETCH_ORDER_CONFLICT = 'swaps-fetch-order-conflict';
 
diff --git a/ui/ducks/swaps/swaps.js b/ui/ducks/swaps/swaps.js
index 3b145a218..a08424869 100644
--- a/ui/ducks/swaps/swaps.js
+++ b/ui/ducks/swaps/swaps.js
@@ -59,6 +59,7 @@ import {
 import {
   ERROR_FETCHING_QUOTES,
   QUOTES_NOT_AVAILABLE_ERROR,
+  CONTRACT_DATA_DISABLED_ERROR,
   SWAP_FAILED_ERROR,
   SWAPS_FETCH_ORDER_CONFLICT,
 } from '../../../shared/constants/swaps';
@@ -785,7 +786,10 @@ export const signAndSendTransactions = (history, metaMetricsEvent) => {
     try {
       await dispatch(updateAndApproveTx(finalTradeTxMeta, true));
     } catch (e) {
-      await dispatch(setSwapsErrorKey(SWAP_FAILED_ERROR));
+      const errorKey = e.message.includes('EthAppPleaseEnableContractData')
+        ? CONTRACT_DATA_DISABLED_ERROR
+        : SWAP_FAILED_ERROR;
+      await dispatch(setSwapsErrorKey(errorKey));
       history.push(SWAPS_ERROR_ROUTE);
       return;
     }
diff --git a/ui/pages/swaps/awaiting-swap/awaiting-swap.js b/ui/pages/swaps/awaiting-swap/awaiting-swap.js
index 8c0ab018a..6cd28fff3 100644
--- a/ui/pages/swaps/awaiting-swap/awaiting-swap.js
+++ b/ui/pages/swaps/awaiting-swap/awaiting-swap.js
@@ -33,6 +33,7 @@ import {
   SWAP_FAILED_ERROR,
   ERROR_FETCHING_QUOTES,
   QUOTES_NOT_AVAILABLE_ERROR,
+  CONTRACT_DATA_DISABLED_ERROR,
   OFFLINE_FOR_MAINTENANCE,
   SWAPS_CHAINID_DEFAULT_BLOCK_EXPLORER_URL_MAP,
 } from '../../../../shared/constants/swaps';
@@ -184,6 +185,11 @@ export default function AwaitingSwap({
     descriptionText = t('swapQuotesNotAvailableErrorDescription');
     submitText = t('tryAgain');
     statusImage = <SwapFailureIcon />;
+  } else if (errorKey === CONTRACT_DATA_DISABLED_ERROR) {
+    headerText = t('swapContractDataDisabledErrorTitle');
+    descriptionText = t('swapContractDataDisabledErrorDescription');
+    submitText = t('tryAgain');
+    statusImage = <SwapFailureIcon />;
   } else if (!errorKey && !swapComplete) {
     headerText = t('swapProcessing');
     statusImage = <PulseLoader />;
@@ -283,6 +289,7 @@ AwaitingSwap.propTypes = {
     ERROR_FETCHING_QUOTES,
     QUOTES_NOT_AVAILABLE_ERROR,
     OFFLINE_FOR_MAINTENANCE,
+    CONTRACT_DATA_DISABLED_ERROR,
   ]),
   submittingSwap: PropTypes.bool,
   inputValue: PropTypes.oneOfType([PropTypes.number, PropTypes.string]),
diff --git a/ui/pages/swaps/index.js b/ui/pages/swaps/index.js
index c70da9bf2..05a0d6d42 100644
--- a/ui/pages/swaps/index.js
+++ b/ui/pages/swaps/index.js
@@ -48,6 +48,7 @@ import {
   ERROR_FETCHING_QUOTES,
   QUOTES_NOT_AVAILABLE_ERROR,
   SWAP_FAILED_ERROR,
+  CONTRACT_DATA_DISABLED_ERROR,
   OFFLINE_FOR_MAINTENANCE,
 } from '../../../shared/constants/swaps';
 
@@ -136,7 +137,7 @@ export default function Swap() {
     tradeTxData?.txReceipt?.status === '0x0';
   const conversionError = approveError || tradeError;
 
-  if (conversionError) {
+  if (conversionError && swapsErrorKey !== CONTRACT_DATA_DISABLED_ERROR) {
     swapsErrorKey = SWAP_FAILED_ERROR;
   }